USP14: STRUCTURE, FUNCTION, AND TARGET INHIBITION

USP14: Structure, Function, and Target Inhibition

Ubiquitin-specific protease 14 (USP14), a deubiquitinating enzyme (DUB), is associated with proteasomes and exerts a dual function in regulating protein degradation.USP14 protects protein substrates from degradation by removing ubiquitin chains from proteasome-bound substrates, whereas promotes protein degradation by activating the proteasome.Incre

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Component-resolved evaluation of the content of major allergens in therapeutic extracts for specific immunotherapy of honeybee venom allergy

Allergen-specific immunotherapy is the only curative treatment of honeybee venom (HBV) allergy, which is able to protect against further anaphylactic sting reactions.Recent analyses on a molecular level have demonstrated that HBV represents a complex allergen source that contains more relevant major allergens than formerly anticipated.Moreover, all

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Management of Speed: The Low-Cost, Rapidly Implementable Effective Road Safety Action to Deliver the 2020 Road Safety Targets

Delivery of road safety is an urgent global priority, as recognised by key events over recent years.The establishment of the United Nations (UN) Decade of Action for Road Safety and the subsequent development of the UN Global Plan for the Decade of Action for Road Safety 2011-2020 (UNRSC, 2011) provided global Rear Camera impetus to focus on elimin

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